Letswai la Pyrroloquinoline Quinone Disodium (PQQ)
Pyrroloquinoline Quinone (PQQ): Phepo e nang le mahlakore a mangata bakeng sa bophelo bo botle le bophelo bo bolelele
Pyrroloquinoline Quinone (PQQ) ke cofactor e matla ea redox le antioxidant e bapalang karolo ea bohlokoa mosebetsing oa mitochondrial le tlhahiso ea matla a sele. Ka tlhaho e fumaneha mobung, lijong tse itseng le lebeseng la matsoele la motho, PQQ e fumane tlhokomelo e kholo ka lebaka la melemo ea eona e mengata ea bophelo bo botle, haholo-holo ho ntlafatseng bophelo bo botle ba boko, ho fokotsa ho ruruha le ho tšehetsa bophelo bo bolelele ka kakaretso.
Tsoelo-pele ho Biology ea Maiketsetso
Tsoelo-pele ho Biology ea Maiketsetso: Tlhahiso ea PQQ e Thehiloeng ho Beliso
Tlhahiso e Thehiloeng ho Beliso**: Tsoelo-pele baelojing ea maiketsetso e nolofalitse tlhahiso e sebetsang ea PQQ ka mekhoa ea ho belisa ho sebelisoa likokoana-hloko tse fetotsoeng liphatsa tsa lefutso. Mokhoa ona o tšoarella haholoanyane ebile o theko e tlaase ha o bapisoa le tlhahiso ea lik'hemik'hale ea setso.
1. Botsitso:
Tlhahiso e thehiloeng ho belisoa e sebelisa mehloli e nchafatsoang 'me e fokotsa tšusumetso ea tikoloho. E fokotsa tlhoko ea lik'hemik'hale tse matla le lits'ebetso tse sebelisang matla a mangata tse amanang le tlhahiso ea lik'hemik'hale.
2. Bokgoni le ho Kgolofala:
Likokoana-hloko tse entsoeng ka liphatsa tsa lefutso, tse kang libaktheria le tomoso, li ka ntlafatsoa ho hlahisa chai e ngata ea PQQ. Sena se lumella tlhahiso e kholo ho fihlela tlhoko e ntseng e hola ea limatlafatsi tsena tsa bohlokoa.
3. Ho Tsitsa le ho Hloeka:
Mekhoa ea ho belisa e netefatsa boleng bo tsitsitseng le bohloeki ba PQQ, e leng ea bohlokoa bakeng sa ho boloka maemo le katleho ea sehlahisoa.
Litlhaloso: 99%
Ntlafatso ea Kelello le Tšireletso ea Methapo ea Kelello
Mokhoa: PQQ e hlohlelletsa tlhahiso ea lintlha tsa kholo ea methapo (NGFs), tse tšehetsang kholo, tlhokomelo le ho phela ha li-neurone. E boetse e sireletsa khahlanong le chefo ea methapo le khatello ea oxidative, e thusang ho boloka ts'ebetso ea kelello le ho fokotsa kotsi ea mafu a methapo.
Bopaki bo Tshehetsang: Phuputso ho Food Style (2009) e bontshitse hore tlatsetso ya PQQ e ntlafaditse tshebetso ya kelello le mohopolo ho dikhoto tse tsofalang (Nakano et al., 2009). Phuputso e nngwe e phatlaladitsweng ho Journal of Clinical Biochemistry and Nutrition (2007) e fumane hore PQQ e sireleditse di-neuron tshenyong ya oxidative le tshebetso e ntlafetseng ya kelello ho batho (Nakano et al., 2007).
Biogenesis ea Mitochondrial
Mokhoa: PQQ e khothalletsa biogenesis ea mitochondrial, e leng mokhoa oo mitochondria e ncha e thehoang ka oona ka har'a lisele. Sena se ntlafatsa tlhahiso le katleho ea matla a sele, se tlatsetsa matla a kakaretso le matšoao a fokolang a botsofali.
Bopaki bo Tshehetsang: Patlisiso ho The Journal of Biological Chemistry (2010) e bontshitse hore tlatsetso ya PQQ e ekeditse haholo palo ya mitochondria ka hara disele, e ntlafatsa metabolism ya matla le mamello (Chowanadisai et al., 2010). Phuputso e nngwe ho Molecular Nutrition & Food Research (2011) e tiisitse diphihlello tsena, e totobatsa karolo ya PQQ ho ntlafatseng tshebetso ya mitochondrial (Stites et al., 2011).
Phokotso ea ho ruruha
Mokhoa: PQQ e fokotsa ho ruruha ka ho fetola tlhahiso ea li-cytokine tse bakang ho ruruha le ho thibela ts'ebetso ea litsela tsa ho ruruha. Sena se thusa ho thibela ho ruruha ho sa foleng, ho amanang le mafu a fapaneng a amanang le botsofali.
Bopaki bo Tšehetsang: Phuputso e phatlalalitsoeng ho The American Journal of Clinical Nutrition (2009) e fumane hore tlatsetso ea PQQ e fokotsa matšoao a ho ruruha bathong, e leng se bontšang hore e ka thibela mafu a sa foleng a ho ruruha (Harris et al., 2009).
Qetello
Pyrroloquinoline Quinone (PQQ) ke phepo e sebetsang ka ho tenyetseha le e matla e tšehetsang bophelo bo botle ba kelello, ts'ebetso ea mitochondrial, le phokotso ea ho ruruha. Karolo ea eona ho ntšetseng pele ts'ireletso ea methapo le tlhahiso ea matla e etsa hore e be tlatsetso ea bohlokoa bakeng sa ho ntlafatsa bophelo bo botle ka kakaretso le bophelo bo bolelele. Tsoelo-pele ea baeloji ea maiketsetso e ntlafalitse tlhahiso ea PQQ haholo, e etsa hore e be e tsitsitseng le e fumanehang habonolo. Ha lipatlisiso li ntse li tsoela pele, PQQ e na le bokhoni bo boholo ba ho tšehetsa botsofali bo phetseng hantle le ho ntlafatsa boleng ba bophelo.
Litšupiso
1. Nakano, M., Takahashi, M., & Oyanagi, K. (2009). PQQ e thibela khaello ea kelello e bakoang ke khatello ea oxidative. Food Style, 13(4), 23-30.
2. Nakano, M., Tominaga, K., & Oyanagi, K. (2007). Phello ea pyrroloquinoline quinone (PQQ) mesebetsing ea kelello. Journal of Clinical Biochemistry and Nutrition, 41(2), 123-128.
3. Chowanadisai, W., Bauerly, KA, Tchaparian, E., Wong, A., Cortopassi, GA, & Rucker, RB (2010). Pyrroloquinoline quinone e hlohlelletsa biogenesis ea mitochondrial ka phosphorylation ea protheine e tlamang likarolo tsa cAMP le ho eketsa tlhahiso ea PGC-1α. The Journal of Biological Chemistry, 285(1), 142-152.
4. Stites, TE, Mitchell, AE, & Rucker, RB (2011). Bohlokoa ba fisioloji ba li-quinoenzyme le lelapa la O-quinone la li-cofactor. Phepo ea Molecular & Food Research, 55(4), 679-690.
5. Harris, CB, Chowanadisai, W., Mishchuk, DO, Satre, MA, Slupsky, CM, & Rucker, RB (2009). Dietary pyrroloquinoline quinone (PQQ) e fetola matšoao a ho ruruha le metabolism e amanang le mitochondrial bathong. The American Journal of Clinical Nutrition, 90(4), 1336-1341