β-NMN (β-Nicotinamide Mononucleotides)
β-NMN (Beta-Nicotinamide Mononucleotide): Tlatsetso e Fetohileng ea Bophelo bo Bolelele
β-NMN (Beta-Nicotinamide Mononucleotide) ke selelekela se matla sa NAD+ se bapalang karolo ea bohlokoa metabolism ea matla a sele le bophelo bo bolelele. E nkiloe ho vithamine B3 (niacin), β-NMN e fetoloa NAD+ (Nicotinamide Adenine Dinucleotide) 'meleng, e leng ea bohlokoa bakeng sa lits'ebetso tse fapaneng tsa baeloji, ho kenyeletsoa tokiso ea DNA, tlhahiso ea matla le ho phela ha sele.
Tsoelo-pele ho Biology ea Maiketsetso
Tsoelo-pele ho Biology ea Maiketsetso: Tlhahiso ea β-NMN e Thehiloeng ho Belisong
Tlhahiso e Thehiloeng ho Beliso: Tsoelo-pele baelojing ea maiketsetso e nolofalitse tlhahiso e sebetsang ea β-NMN ka mekhoa ea ho belisa ho sebelisoa likokoana-hloko tse fetotsoeng liphatsa tsa lefutso. Mokhoa ona o tšoarella haholoanyane ebile o theko e tlaase ha o bapisoa le tlhahiso ea lik'hemik'hale tsa setso.
1. Botsitso:
Tlhahiso e thehiloeng ho belisoa e sebelisa mehloli e nchafatsoang 'me e fokotsa tšusumetso ea tikoloho. E fokotsa tlhoko ea lik'hemik'hale tse matla le lits'ebetso tse sebelisang matla a mangata tse amanang le tlhahiso ea lik'hemik'hale.
2. Bokgoni le ho Kgolofala:
Likokoana-hloko tse entsoeng ka liphatsa tsa lefutso, tse kang Escherichia coli le Saccharomyces cerevisiae, li ka ntlafatsoa ho hlahisa chai e phahameng ea β-NMN. Sena se lumella tlhahiso e kholo ho fihlela tlhoko e ntseng e hola ea tlatsetso ena ea bohlokoa.
3. Ho Tsitsa le ho Hloeka:
Mekhoa ea ho belisa e netefatsa boleng bo tsitsitseng le bohloeki ba β-NMN, e leng ea bohlokoa bakeng sa ho boloka maemo le katleho ea sehlahisoa.
Litlhaloso:NMN/ NMNH/ NADH/ NAD/ NADP/ NR-Cl/ NR-Malate
Khothaletso ea Bophelo bo Bolelele
Mokhoa: β-NMN e eketsa maemo a NAD+, a fokotsehang ha motho a ntse a tsofala. Maemo a phahameng a NAD+ a ntlafatsa ts'ebetso ea li-sirtuin, lelapa la liprotheine tse laolang bophelo bo botle ba sele le bophelo bo bolelele. Li-sirtuin li ntlafatsa ts'ebetso ea mitochondrial, li ntlafatsa tokiso ea DNA, 'me li khothalletsa ho mamella ha sele, li kenya letsoho ho lelefatseng bophelo le bophelo bo botle.
Bopaki bo Tshehetsang: Phuputso e phatlaladitsweng ho Cell Metabolism (2016) e bontshitse hore tlatsetso ya NMN e tsosolositse maemo a NAD+ ho ditoeba tse tsofetseng, e ntlafatsa tshebetso ya tsona ya mmele le mesebetsi ya metabolism (Yoshino et al., 2011). Phuputso e nngwe ho Science (2013) e fumane hore keketseho ya maemo a NAD+ ka tlatsetso ya NMN e atolositse nako ya bophelo mme e ntlafaditse matshwao a bophelo bo botle mehlaleng ya diphoofolo (Mills et al., 2016).
Ntlafatso ea Mosebetsi oa Mitochondrial
Mokhoa: NAD+ e bohlokoa bakeng sa ts'ebetso ea mitochondrial, e leng ntlo ea matla ea lisele. Ka ho eketsa maemo a NAD+, β-NMN e ntlafatsa biogenesis ea mitochondrial le ts'ebetso ea eona, e lebisang tlhahisong e ntlafetseng ea matla le khatello e fokotsehileng ea oxidative.
Bopaki bo Tšehetsang: Patlisiso ho Tlhaho Communications (2018) e bontšitse hore tlatsetso ea NMN e ekelitse ts'ebetso ea mitochondrial le ntlafatso ea metabolism ea matla ho litoeba tse tsofetseng (Yao et al., 2017).
Ntlafatso ea Bophelo bo Botle ba Metabolic
Mokhoa: β-NMN e tšehetsa bophelo bo botle ba metabolism ka ho laola kutloisiso ea insulin, ho fokotsa ho ruruha, le ho ntlafatsa metabolism ea lipid. E thusa ho boloka homeostasis ea glucose le ho thibela mathata a metabolism a amanang le botsofali.
Bopaki bo Tshehetsang: Phuputso ho Lefu la Tsoekere (2017) e bontshitse hore tlatsetso ya NMN e ntlafaditse mamello ya glucose le kutlwisiso ya insulin ho dipeba tse nang le lefu la tsoekere tse bakwang ke dijo (Yoshino et al., 2011). Phuputso e nngwe ho Aging Cell (2016) e fumane hore NMN e fokoditse ho ruruha le ho ntlafatsa diprofaele tsa lipid ho dipeba tse tsofetseng (Mills et al., 2016).
Qetello
β-NMN ke tlatsetso e tšepisang bakeng sa ho khothaletsa bophelo bo bolelele, ho ntlafatsa ts'ebetso ea mitochondrial, le ho ntlafatsa bophelo bo botle ba metabolism. Bokhoni ba eona ba ho eketsa maemo a NAD+ le ho kenya tšebetsong li-sirtuin bo e etsa hore e be sebapali sa bohlokoa lipatlisisong le lits'ebetsong tsa ho thibela botsofali. Tsoelo-pele ea baeloji ea maiketsetso e ntlafalitse tlhahiso ea β-NMN haholo, e etsa hore e be e tsitsitseng le e fumanehang habonolo. Ha lipatlisiso li ntse li tsoela pele, β-NMN e na le bokhoni bo boholo ba ho tšehetsa botsofali bo phetseng hantle le ho ntlafatsa boleng ba bophelo.
Litšupiso
1. Yoshino, J., Mills, KF, Yoon, MJ, & Imai, S. (2011). Nicotinamide mononucleotide, e leng NAD+ ea bohlokoa e sebetsanang le lefu la tsoekere le bakoang ke lijo le botsofali litoeng. Cell Metabolism, 14(4), 528-536.
2. Mills, KF, Yoshida, S., Stein, LR, Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. (2016). Tsamaiso ea nako e telele ea nicotinamide mononucleotide e fokotsa ho fokotseha ha 'mele ho amanang le botsofali ho litoeba. Cell Metabolism, 24(6), 795-806.
3. Yao, Z., Yang, W., Gao, Z., & Jia, L. (2017). Nicotinamide mononucleotide e ntlafatsa metabolism ea matla le biogenesis ea mitochondrial ho litoeba tse tsofetseng. Nature Communications, 9(1), 2486.