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Nicotinamide Adenine Dinucleotide

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Lebitso le leng: NAD+, Nicotinamide Adenine Dinucleotide (mofuta o nang le oxidized)
Mokhoa oa tlhahiso: Baeloji ea Maiketsetso
Ponahalo: Phofo e tšoeu ea kristale
Nomoro ea CAS: 53-84-9
Boima ba limolek'hule: 663.43 g/mol

Litlhaloso:99%

    Iteanye le rona
    Tlhahisoleseding
    Litlhaloso
    Melemo
    β-NAD+ ke coenzyme ea bohlokoa e fumanoang liseleng tsohle tse phelang, e bapala karolo ea bohlokoa metabolism ka ho thusa ho fetisetsa lielektrone liketsong tsa redox. Ke ea bohlokoa tlhahisong ea matla, tokiso ea DNA, le ho laola lits'ebetso tsa sele tse amanang le botsofali. Maemo a β-NAD+ a fokotseha ka tlhaho ha a ntse a tsofala, 'me tlatsetso e ka thusa ho tsosolosa ts'ebetso e ntle ea sele le ho khothaletsa bophelo bo bolelele.
    Litlhaloso: 99%
    Tlhahiso ea matla: β-NAD+ e bohlokoa bakeng sa tlhahiso ea ATP, e ntlafatsa ts'ebetso ea mitochondrial le ho khothaletsa maemo a matla ka kakaretso【Yoshino et al., 2018】.
    Tokiso ea DNA: β-NAD+ e kenya tšebetsong lienzyme tse kang li-PARP, tse thusang ho lokisa tšenyo ea DNA, tse tšehetsang bophelo bo botle ba sele le bophelo bo bolelele [Belenky et al., 2007].
    Thibelo ea botsofali le bophelo bo bolelele: β-NAD+ e bapala karolo ea bohlokoa ho qaleng li-sirtuin, li-enzyme tse amanang le bophelo bo bolelele, ho ntlafatsa bophelo bo botle ba metabolism le ho liehisa mekhoa ea botsofali【Gomes et al., 2013】.
    Mosebetsi oa kelello: Tlatsetso ea NAD+ e bontšitsoe e tšehetsa bophelo bo botle ba boko, e ntlafatsa mohopolo, le ho ntlafatsa ts'ebetso ea kelello【Vaur et al., 2017】.

    Mekhoa

    β-NAD+ e sebetsa e le coenzyme liketsong tsa redox, e thusang ho fetisetsa lielektrone nakong ea ho hema ha sele le tlhahiso ea ATP mitochondria. E boetse e bapala karolo ea bohlokoa ho kenngoeng ha sirtuin, e laolang tokiso ea DNA, ho ruruha le litsela tsa metabolism tse amanang le botsofali【Yoshino et al., 2018】. β-NAD+ e tšehetsa ts'ebetso ea li-enzyme tsa PARP, tse thusang ho boloka botsitso ba genomic le ts'ebetso ea sele【Belenky et al., 2007】.

    Litšupiso

    Yoshino, J., et al. (2018). Babuelli ba NAD+: Baeloji le bokgoni ba kalafo ba NMN le NR. Metabolism ya Sele.
    Belenky, P., et al. (2007). Metabolism ea NAD+ bophelong bo botle le mafung. Sele.
    Gomes, AP, et al. (2013). Ho fokotseha ha NAD+ ho baka boemo ba pseudohypoxic bo sitisang puisano ea nuclear-mitochondria nakong ea botsofali. Sele.
    Vaur, P., et al. (2017). Metabolism ea NAD+ e le sepheo sa kalafo bakeng sa mafu a senyehang a amanang le botsofali. Journal of Clinical Investigation.