Tumellano ea Saense ea Lefatše ka Bophara e Netefatsa Melemo ea Bophelo bo Botle ba Quercetin ea Litsamaiso tse Ngata: Litumello tsa Taolo ea FDA le ea Machaba li Bula Tsela ea Likopo tsa Bongaka

2025-08-11

Maemo a bopaki a ho phahamisa quercetin—flavonoid e matla e tswang dimeleng—e le motheo wa ho lwantsha mafu a amanang le botsofadi ka ho fetola kgatello ya oxidative, ho ruruha le ho se sebetse hantle ha metabolism. Ditumello tsa taolo (FDA, Japane, Korea) di tiisa polokeho e le Tlatsetso ea Lijo.

I. Mehloli ea Tlhaho le Profaele ea Lik'hemik'hale tsa Baeloji

Mehloli e ka Sehloohong (Tekanyo e tloaelehileng ea letsatsi le letsatsi: 25–50 mg):
Lieiee (>100 mg/100g), liapole, tee e tala, li-cherries, morara o mofubelu, cilantro.
Mosebetsi o phelang:
Lihlopha tse 5 tsa hydroxyl li nolofalletsa ho se sebetse hantle ha li-free radical (H₂O₂, O₂⁻), tse sebetsang hantle ho feta li-antioxidants tse tloaelehileng.

II. Mekhoa ea Liketso: Litsela tsa Limolek'hule

① Sistimi ea Tšireletso ea Antioxidant

E kenya tshebetsong tsela ya Nrf2/ARE → ↑polelo ya SOD/GPx
E thibela kopano ea NADPH oxidase (NOX) → ↓Tlhahiso ea ROS ka 68% (Botsofali ba Sele, 2023)

② Bokgoni ba ho Thibela ho Ruruha

E thibela lets'oao la NF-κB → ↓TNF-α/IL-6 (phokotso ea 70% mefuteng ea psoriasis ea murine)
Li-block tsa STAT3 phosphorylation → E emisa axis ea IL-23/IL-17A

III. Litšebeliso tsa Kalafo ho Mafu

Boemo	Phello e Bonoeng	Mokhoa
Ho senyeha ha methapo ea kutlo	Li-plaque tsa ↓β-amyloid; ho hlaphoheloa kelellong	Ho kenella ha mokoallo oa mali bokong
Lefu la tsoekere	Glucose e itimang lijo ↓15%; ↑Tlhaloso ea GLUT4	Ho kenngwa tshebetsong ha AMPK (+ tshebedisano mmoho ya metformin)
Kankere (Sefuba/Mala o Monyenyane)	Ho fokotseha ha hlahala; ho hlahisoa ha apoptosis	Ho emisoa ha potoloho ea sele ea G2; thibelo ea angiogenesis
Pelo le methapo ea mali	Li-plaque tsa atherosclerotic ↓40%	Ho feto-fetoha ha ACAT/PPARα; ↑ho oxidation ea asiti e mafura

IV. Litharollo tsa Bioavailability le Polokeho

Phephetso ea ho Monya: 5–10% ea motheo → 81% ka:
- Hydrolysis ea Glycoside
- Ho kopanngoa ha vithamine C/mafura
Tekanyo: ≤1,000 mg/letsatsi (Litekanyo tse phahameng li ka baka litlamorao tse mpe tsa ho baka oksijene)
Tšebelisano ea Lithethefatsi: E thibetsoe ho sebelisa lithibela-mafu/lithibela-mafu

V. Litaelo tsa Nakong e Tlang: Phano e Nepahetseng

Ho Koaheloa ha Nano (PLGA/liposomes) e matlafatsa ho shebana le hlahala
Likamano tse Amohetsoeng ke FDA: Quercetin-mekhoa ea phosphatidylcholine (US5043323)