Litlamorao tse 7 tsa Berberine Hydrochloride
Berberine hydrochloride matlapa, a tsejoang haholo e le "Huang Lian Su", ke meriana ea letšollo e rekisoang ntle ho lengolo la ngaka Chaena. Ke alkaloid e kholo e fumanoang ka har'a rhizome ea semela sa Ranunculaceae Coptis Chineseensis, 'me e ka ntšoa ho Barbary aristata, Phellodendron Chinesenensekapa Gnaphalium affinisMatlapa a Berberine hydrochloride a na le lits'ebetso tse fapaneng tsa bongaka, haholo-holo ho kenyeletsoa tse latelang:
(A) Mafu a Sisteme ea tšilo ea lijo
1. Tšoaetso ea mala: tse kang gastroenteritis, letšollo, letšollo, jj.
Tlhaloso: Berberine hydrochloride e na le phello e thibelang likokoana-hloko tse fapaneng tsa Gram-positive le Gram-negative, haholo-holo likokoana-hloko tse fapaneng tse bakang mafu tse kang hemolytic streptococci le Staphylococcus aureus.
2. Seso sa mala: E na le phello e thibelang Helicobacter pylori, e ka fokotsang chefo ea tšoaetso ea Helicobacter pylori liseleng, ka hona e thusa kalafong ea seso sa peptic.
Tlhaloso: Mokhoa oa ketso ea berberine hydrochloride Matlapa a phekolang liso tsa peptic a kenyeletsa haholo-holo antibacterial (anti-Helicobacter pylori), anti-inflammatory, tšireletso ea mucosal ea mpa, thibelo ea ho ntšoa ha asiti ea mpa, le ntlafatso ea ts'ebetso ea mala. Ka bongaka, hangata e sebelisoa hammoho le meriana e meng (e kang li-proton pump inhibitors le lithibela-mafu) ho ntlafatsa phello ea phekolo.
3. Cholecystitis e sa folengKalafo e kopaneng le matlapa a trisulfide bakeng sa cholecystitis e sa foleng ho batho ba hōlileng e ka fokotsa boemo ba mabaka a ho ruruha serum ea mokuli le ho ntlafatsa matšoao a kliniki.
Tlhaloso: Lithuto tsa bongaka li bontšitse hore motsoako oa berberine hydrochloride Matlapa le matlapa a anethole trisulfide a sebetsa hantle haholo ho feta matlapa a anethole trisulfide feela ho phekoleng cholecystitis e sa foleng ho batho ba hōlileng. Matšoao a bongaka a bakuli a ntlafala haholo 'me maemo a mabaka a ho ruruha a fokotsehile haholo.
4. Lefuba la liso: Ho kopanya mesalazine kapa sulfasalazine le meriana e meng ho phekola lefu la ho ruruha ha diso ho ka fokotsa karabelo ya ho ruruha haholo, ha ntlafatsa matshwao a kliniki, mme ha kgothaletsa ho hlaphoheloa ha mosebetsi wa thibelo ya mala.
Tlhaloso: Berberine hydrochloride e kenella ho pathogenesis ea ulcerative colitis ka litsela tse ngata, 'me e na le litlamorao tse khahlanong le ho ruruha, ho laola sesole sa' mele le ho sireletsa mala, e leng se etsang hore e be moriana o thusang o tšepisang.
(B) Mafu a Tshebetso ea Metabolism
1. Lefu la tsoekere la Mofuta oa 1 le oa 2: Maemo a tsoekere maling a ka laoloa ka ho a sebelisa a le mong kapa hammoho le meriana ea Bophirimela (joalo ka metformin, glipizide, jj.).
Tlhaloso: Berberine hydrochloride Matlapa a bapala karolo e ntle kalafong ea lefu la tsoekere la mofuta oa 2 ka mekhoa e mengata, ho kenyeletsoa ho ntlafatsa ho hanyetsa insulin, ho theola tsoekere maling, ho laola mafura maling, litlamorao tsa ho thibela ho ruruha le ho thibela ho ruruha, le ho laola microbiota ea mala. Katleho ea eona e totobetse, polokeho ea eona e ntle, 'me e loketse haholo maano a phekolo ea motsoako.
2. Hyperlipidemia: E ka laola mafura a mali ka katleho, ea fokotsa maemo a k'holeseterole eohle (TC) le triglycerides (TG) maling, 'me ea eketsa k'holeseterole ea lipoprotein e nang le density e phahameng (HDL-C). Ha e sebelisoa hammoho le li-statin (tse kang atorvastatin le rosuvastatin), phello ea ho theola mafura e ka ntlafatsoa le ho feta.
Tlhaloso: Lithuto tsa bongaka li bontša hore berberine e ka fokotsa maemo a k'holeseterole eohle, k'holeseterole ea LDL le triglyceride, ka phokotso ea ho fihla ho 20-50 mg/dL le 25-55 mg/dL, ka ho latellana. Ka hona, berberine hydrochloride Matlapa a na le phello e ntle ea ho fokotsa mafura 'me a loketse haholo bakuli ba sa mamelleng li-statin.
3. Lefu la methapo ea kutlo la lefu la tsoekere: E thibela ho kenngwa tshebetsong ha aldose reductase, e fokotsa ho bokellana ha sorbitol, mme e sireletsa tshebetso ya methapo.
Tlhaloso: Berberine hydrochloride e ntlafatsa sebopeho sa methapo le ts'ebetso ea lefu la tsoekere le methapo ea kutlo ka mokhoa o kopaneng oa "thibelo ea ho ruruha + antioxidant + anti-apoptosis + taolo ea metabolism", e nang le motheo oa saense le litebello tsa kliniki e le phekolo e thusang.