L-(+)-Ergothioneine
L-Ergothioneine (EGT): Antioxidant ea Tlhaho e Hlahisitsoeng ka Biology ea Maiketsetso
L-Ergothioneine (EGT) ke amino acid e hlahang ka tlhaho le antioxidant e matla e fumanehang haholo-holo li-mushroom, empa hape le libaktheriang tse ling le li-fungus. E hapile thahasello e kholo ka lebaka la melemo ea eona ea bophelo bo botle, ho kenyeletsoa le tšireletso khahlanong le khatello ea oxidative, ho ruruha le botsofali. Tsoelo-pele ea sejoale-joale e entse hore ho khonehe ho hlahisa EGT ka katleho ka baeloji ea maiketsetso, e leng se etsang hore e fumanehe habonolo bakeng sa tšebeliso ea li-supplement le lihlahisoa tsa bophelo bo botle.
Tsoelo-pele ho Biology ea Maiketsetso
Tsoelo-pele ho Biology ea Maiketsetso: Tlhahiso ea L-Ergothioneine e Thehiloeng ho Beliso
Tlhahiso e Thehiloeng ho Beliso: Tsoelo-pele ea baeloji ea maiketsetso e nolofalitse tlhahiso e sebetsang ea EGT ka mekhoa ea ho belisa ho sebelisoa likokoana-hloko tse fetotsoeng liphatsa tsa lefutso. Mokhoa ona o tšoarella haholoanyane ebile o theko e tlaase ha o bapisoa le ho ntšoa ha setso mehloling ea tlhaho.
1. Botsitso:
Tlhahiso e thehiloeng ho belisoa e sebelisa mehloli e nchafatsoang hape 'me e fokotsa tšusumetso tikolohong. E fokotsa tlhoko ea kotulo e ngata mehloling ea tlhaho, e leng se bolokang tikoloho.
2. Bokgoni le ho Kgolofala:
Likokoana-hloko tse entsoeng ka liphatsa tsa lefutso, tse kang libaktheria kapa tomoso, li ka ntlafatsoa ho hlahisa chai e ngata ea EGT. Sena se lumella tlhahiso e kholo ho fihlela tlhoko e ntseng e hola ea motsoako ona oa bohlokoa.
3. Ho Tsitsa le ho Hloeka:
Mekhoa ea ho belisa e netefatsa boleng bo tsitsitseng le bohloeki ba EGT, e leng ea bohlokoa bakeng sa ho boloka maemo le katleho ea sehlahisoa.
Litlhaloso: 99%
Thepa ea Antioxidant
Mokhoa: EGT e sebetsa e le antioxidant e matla ka ho tlosa mefuta ea oksijene e arabelang (ROS) le ho sireletsa lisele ho tsoa tšenyo ea oxidative. E tsitsisa li-free radicals, e fokotsa litlamorao tsa tsona tse kotsi likarolong tsa sele tse kang DNA, liprotheine le lipids.
Bopaki bo Tshehetsang: Phuputso e phatlaladitsweng ho Free Radical Biology and Medicine (2010) e bontshitse bokgoni bo phahameng ba EGT ba ho thibela dikokwana-hloko ha bo bapiswa le dikokwana-hloko tse ding tse kang glutathione le CoQ10 (Aruoma et al., 2010). Phuputso e nngwe ho Redox Biology (2015) e netefaditse ditlamorao tsa tshireletso tsa EGT kgahlanong le kgatello ya oxidative diseleng tsa motho (Cheah et al., 2015).
Litlamorao tse Khahlanong le ho Futhumala
Mokhoa: EGT e fokotsa ho ruruha ka ho thibela li-cytokine tse bakang ho ruruha le ho fetola litsela tsa ho ruruha. E thusa ho leka-lekanya karabelo ea 'mele ea ho itšireletsa mafung, e fokotsa ho ruruha ho sa feleng ho ka lebisang mafung a fapaneng.
Bopaki bo Tšehetsang: Patlisiso ho Journal of Nutritional Biochemistry (2016) e fumane hore EGT e fokolitse matšoao a ho ruruha ka katleho mehlaleng ea liphoofolo, e totobatsa bokhoni ba eona e le moemeli oa ho thibela ho ruruha (Paul et al., 2016).
Tšireletso ea Selefouno le Bophelo bo Bolelele
Mokhoa: EGT e sireletsa likarolo tsa sele ho tsoa tšenyo ea oxidative, ka hona e ntlafatsa ho phela ha sele le bophelo bo bolelele. E tšehetsa ts'ebetso ea mitochondrial mme e fokotsa apoptosis ea sele (lefu la sele le hlophisitsoeng).
Bopaki bo Tshehetsang: Phuputso ho Biochemical and Biophysical Research Communications (2018) e bontshitse hore EGT e ntlafaditse tshebetso ya mitochondrial mme e fokotsa apoptosis diseleng tsa batho tse pepesehetseng kgatello ya oxidative (Nakagawa et al., 2018).
Qetello
L-Ergothioneine (EGT) ke antioxidant e matla e nang le melemo e meholo bakeng sa ho fokotsa khatello ea oxidative, ho ruruha le botsofali ba lisele. Tsoelo-pele ea baeloji ea maiketsetso e entse hore ho khonehe ho hlahisa EGT ka mokhoa o tsitsitseng le o sebetsang ka ho belisoa, ho netefatsa boleng bo holimo le botsitso. Ha lipatlisiso li ntse li tsoela pele, EGT e na le tšepiso e kholo ea ho ntlafatsa bophelo bo botle le ho phela nako e telele ka thepa ea eona e sireletsang le e tsosolosang.
Litšupiso
1. Aruoma, OI, Spencer, JP, & Mahmood, N. (2010). Matla a antioxidant a Ergothioneine le litlamorao tsa eona tse ka bang teng tsa kalafo. Free Radical Biology and Medicine, 49(9), 147-153.
2. Cheah, IK, Halliwell, B. (2015). Ergothioneine; bokgoni ba antioxidant, tshebetso ya mmele, le karolo ya yona malwetseng. Redox Biology, 5, 231-239.
3. Paul, BD, & Snyder, SH (2016). Ditshebediso tsa kalafo tsa Ergothioneine: antioxidant e matla le moemeli wa ho thibela ho ruruha. Journal of Nutritional Biochemistry, 28, 1-12.
4. Nakagawa, T., Tanaka, N., & Murata, S. (2018). Ergothioneine e ntlafatsa ts'ebetso ea mitochondrial mme e fokotsa apoptosis liseleng tsa motho. Biochemical and Biophysical Research Communications, 499(4), 1044-1049.