Fisetin
Fisetin: Antioxidant e Matla bakeng sa Bophelo bo Botle le Bophelo bo Bolelele
Fisetin, flavonoid e fumanehang ka tlhaho e fumanoang litholoana le merohong e fapaneng joalo ka fragole, liapole le lieiee, e ntse e hapa tlhokomelo ka lebaka la melemo ea eona e ikhethang ea bophelo bo botle. E tsebahala ka thepa ea eona e matla ea antioxidant, anti-inflammatory, le senolytic, fisetin e ntse e ithutoa ka lebaka la bokhoni ba eona ba ho tšehetsa bophelo bo bolelele le ho fokotsa mafu a amanang le botsofali.
Likarolo tse Khōlō tsa Fisetin
Fisetin ka boeona ke karolo e sebetsang ea flavonoid e ikarabellang bakeng sa melemo e fapaneng ea bophelo bo botle. E tsejoa ka lik'hemik'hale e le 3,3', 4', 7-tetrahydroxyflavone. Sebopeho sa eona sa limolek'hule se e lumella ho sebelisana le litsela tse fapaneng tsa baeloji, e leng se lebisang liphellong tsa eona tse fapaneng tsa phekolo.
Likopo ho Litlatsetso tsa Lijo
Fisetin e sebelisoa hangata lijong tse tlatsetsang tse reretsoeng ho tšehetsa bophelo bo botle ba boko, ho fokotsa ho ruruha le ho khothalletsa bophelo bo bolelele. Tekanyo e khothaletsoang ea fapana, empa hangata e tloha ho 100 ho isa ho 500 mg ka letsatsi, ho latela mokhoa o itseng le tšebeliso e reriloeng.
Litlhaloso: 50%-98% (HPLC)
Bokgoni: 50MT/A
Litlamorao tsa Antioxidant le Anti-inflammatory
Mokhoa: Fisetin e na le ts'ebetso e matla ea antioxidant ka ho tlosa li-free radical le ho ntlafatsa ts'ebetso ea li-enzyme tsa antioxidant tsa tlhaho. E boetse e fokotsa ho ruruha ka ho thibela tlhahiso ea li-cytokine tse bakang ho ruruha le ho fokotsa litsela tsa ho ruruha tse kang NF-κB.
Bopaki bo Tšehetsang: Phuputso ho Molek'hule (2019) e totobalitse bokhoni ba fisetin ba ho fokotsa khatello ea oxidative le ho ruruha mefuteng e fapaneng ea lisele le liphoofolo, e leng se bontšang bokhoni ba eona ba ho sireletsa khahlanong le mafu a sa foleng (Khan et al., 2019).
Tšireletso ea methapo ea kutlo
Mokhoa: Fisetin e tšehetsa bophelo bo botle ba boko ka ho khothalletsa ho hlaha ha methapo ea kutlo, ho fokotsa ho ruruha ha methapo ea kutlo, le ho thibela tšenyo ea methapo ea kutlo. E ntlafatsa mohopolo le ts'ebetso ea kelello ka ho fetola litsela tsa lipontšo tse amehang ho plasticity ea synaptic.
Bopaki bo Tšehetsang: Patlisiso ho Meeli ea ho Tsofala Neuroscience (2016) e bontšitse hore fisetin e ntlafalitse ts'ebetso ea kelello le ho fokotsa ho ruruha ha methapo ea kutlo mehlaleng ea liphoofolo ea lefu la Alzheimer's, e leng se bontšang bokhoni ba eona e le moemeli oa tšireletso ea methapo ea kutlo (Currais et al., 2016).
Mosebetsi oa Senolytic
Mokhoa: Fisetin e baka apoptosis liseleng tse seng li hōlile, e leng lisele tse emisitseng ho arohana le ho kenya letsoho botsofaling le mafung a amanang le botsofali. Ka ho hloekisa lisele tsena tse sa sebetseng hantle, fisetin e thusa ho ntlafatsa ts'ebetso ea lisele le ho fokotsa ho ruruha.
Bopaki bo Tšehetsang: Phuputso e phatlalalitsoeng ho EBioMedicine (2018) e bontšitse hore fisetin e felisitse lisele tse sensescent ka khetho 'me e ntlafalitse bophelo bo botle le nako ea bophelo litoebeng, e leng se bontšang karolo ea eona ho ntšetseng pele botsofali bo phetseng hantle (Yousefzadeh et al., 2018).
Qetello
Fisetin ke flavonoid e sebetsang ka mekhoa e mengata le e matla e nang le melemo e mengata ea bophelo bo botle, ho kenyeletsoa le thepa ea antioxidant, anti-inflammatory, neuroprotective le senolytic. Bokhoni ba eona ba ho fetola litsela tse ngata tsa baeloji bo e etsa hore e be mokhethoa ea tšepisang bakeng sa ho khothaletsa bophelo bo botle le bophelo bo bolelele. Lipatlisiso tse tsoelang pele li ntse li tsoela pele ho senola lits'ebetso tsa eona tse ka bang teng ho thibeleng le ho phekoleng maemo a fapaneng a amanang le botsofali.
Litšupiso
1. Khan, N., Afaq, F., & Mukhtar, H. (2019). Fisetin: Antioxidant ea lijo bakeng sa ho ntlafatsa bophelo bo botle. Limolek'hule, 24(6), 1004.
2. Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., & Maher, P. (2016). Ho fetola p25 le litsela tsa ho ruruha ka fisetin ho boloka ts'ebetso ea kelello ho litoeba tse fetotsoeng ke lefu la Alzheimer. Frontiers in Aging Neuroscience, 8, 96.
3. Yousefzadeh, MJ, Zhu, Y., McGowan, SJ, Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & Robbins, PD (2018). Fisetin ke phekolo ea kelello e atolosang bophelo bo botle le nako ea bophelo. EBioMedicine, 36, 18-28.