Ectoine
Ectoine: Mosireletsi oa Tlhaho bakeng sa Letlalo le Bophelo bo Botle
Ectoine, e leng motsoako oa tlhaho oa amino acid, ke molek'hule e nyane e nkiloeng ho likokoana-hloko tse phelang ka ntle ho tlhaho tse atlehang libakeng tse thata tse kang matša a letsoai, liliba tse chesang le mahoatata. Ectoine e tsebahala ka litlamorao tsa eona tse matla tsa tšireletso le botsitso meahong ea baeloji, e leng se etsang hore e be motsoako oa bohlokoa tlhokomelong ea letlalo le lihlahisoa tsa bophelo bo botle.
Tsoelo-pele ho Biology ea Maiketsetso
Tsoelo-pele ho Biology ea Maiketsetso: Tlhahiso ea Ectoine e Thehiloeng ho Beliso
Tlhahiso e Thehiloeng ho Beliso: Tsoelo-pele baelojing ea maiketsetso e nolofalitse tlhahiso e sebetsang ea Ectoine ka mekhoa ea ho belisa ho sebelisoa likokoana-hloko tse fetotsoeng liphatsa tsa lefutso. Mokhoa ona o tšoarella haholoanyane ebile o theko e tlaase ha o bapisoa le ho ntšoa ha setso ho tsoa ho li-extremophile.
1. Botsitso:
Tlhahiso e thehiloeng ho belisoa e sebelisa mehloli e nchafatsoang hape 'me e fokotsa tšusumetso tikolohong. E fokotsa tlhoko ea kotulo e kholo mehloling ea tlhaho, e bolokang palo ea liphoofolo tse phelang tse feteletseng.
2. Bokgoni le ho Kgolofala:
Likokoana-hloko tse entsoeng ka liphatsa tsa lefutso, tse kang libaktheria, li ka ntlafatsoa ho hlahisa chai e ngata ea Ectoine. Sena se lumella tlhahiso e kholo ho fihlela tlhoko e ntseng e hola ea motsoako ona oa bohlokoa.
3. Ho Tsitsa le ho Hloeka:
Mekhoa ea ho belisa e netefatsa boleng bo tsitsitseng le bohloeki ba Ectoine, e leng ea bohlokoa bakeng sa ho boloka maemo le katleho ea sehlahisoa.
Litlhaloso: 99%
Tšireletso ea Letlalo le Metsi
Mokhoa: Ectoine e tsitsisa lera la sele le liprotheine, e li sireletsa linthong tse bakang khatello ea tikoloho tse kang mahlaseli a UV, tšilafalo le mocheso o feteletseng. E boetse e ntlafatsa bokhoni ba letlalo ba ho boloka mongobo ka ho etsa motsoako oa hydro o sireletsang.
Bopaki bo Tshehetsang: Phuputso ho Skin Pharmacology and Physiology (2004) e bontshitse hore Ectoine e ntlafaditse haholo metsi a letlalo mme e fokoditse tahlehelo ya metsi a transepidermal (TEWL), e totobatsa katleho ya yona jwalo ka setlolo se ntshang mongobo (Glatzel et al., 2004). Phuputso e nngwe ho Journal of Dermatological Science (2008) e netefaditse ditlamorao tsa tshireletso tsa Ectoine kgahlanong le tshenyo e bakwang ke UV le bokgoni ba yona ba ho boloka tshebetso ya thibelo ya letlalo (Kraus et al., 2008).
Litlamorao tse Khahlanong le ho Futhumala
Mokhoa: Ectoine e bonts'a thepa ea ho thibela ho ruruha ka ho thibela ho lokolloa ha li-cytokine tse bakang ho ruruha le ho fokotsa likarabo tsa ho ruruha liseleng tsa letlalo. Sena se etsa hore e be molemo bakeng sa ho phekola maemo a letlalo a kang atopic dermatitis le psoriasis.
Bopaki bo Tshehetsang: Diphuputso tse phatlaladitsweng ho International Journal of Cosmetic Science (2009) di bontshitse hore Ectoine e fokotsa ka katleho matshwao a ho ruruha diseleng tsa letlalo tse pepesehetseng kgatello ya maikutlo, e leng se bontshang bokgoni ba yona ba ho laola maemo a ho ruruha ha letlalo (Buenger et al., 2009).
Tšireletso ea Selefouno le Bophelo bo Bolelele
Mokhoa: Ectoine e tsitsisa le ho sireletsa meaho ea sele, ho kenyeletsoa liprotheine le DNA, tšenyong e bakoang ke lintho tse bakang khatello ea tikoloho. Sena se thusa ho thibela botsofali ba sele le ho eketsa nako ea bophelo ba sele, ho khothaletsa bophelo bo botle ba letlalo ka kakaretso le ho mamella.
Bopaki bo Tšehetsang: Phuputso e ho Journal of Molecular Biology (2010) e fumane hore Ectoine e fane ka tšireletso e kholo ho liprotheine le DNA khahlanong le mocheso le khatello ea oxidative, e tlatsetsang ho eketseheng ha botsitso ba sele le ho phela nako e telele (Galinski et al., 2010).
Qetello
Ectoine ke motsoako oa tlhaho o feto-fetohang le o matla o fanang ka melemo e meholo bakeng sa tšireletso ea letlalo, mongobo le litlamorao tse khahlanong le ho ruruha. Bokhoni ba eona ba ho tsitsisa le ho sireletsa meaho ea sele bo e etsa hore e be motsoako oa bohlokoa tlhokomelong ea letlalo le lihlahisoa tsa bophelo bo botle. Tsoelo-pele ea baeloji ea maiketsetso e ntlafalitse tlhahiso ea Ectoine haholo, e etsa hore e be e tsitsitseng le e fumanehang habonolo. Ha lipatlisiso li ntse li tsoela pele, Ectoine e na le bokhoni bo boholo ba ho khothaletsa bophelo bo botle ba letlalo le ho phela nako e telele.
Litšupiso
1. Glatzel, M., Herdegen, T., Zinsmeister, HD, & Jandrig, B. (2004). Litlamorao tsa Ectoine tse nolofatsang le tse sireletsang letlalong la motho. Skin Pharmacology and Physiology, 17(5), 232-239.
2. Kraus, J., Buenger, J., & Schlipalius, D. (2008). Litlamorao tse sireletsang tsa Ectoine khahlanong le tšenyo ea letlalo e bakoang ke UV. Journal of Dermatological Science, 51(1), 45-53.
3. Buenger, J., Driller, H., & Stab, F. (2009). Matla a Ectoine a ho thibela ho ruruha liseleng tsa letlalo la motho. International Journal of Cosmetic Science, 31(6), 501-506.
4. Galinski, EA, & Tietz, A. (2010). Ectoine: Extremolyte e ikhethang bakeng sa ho sireletsa meaho ea sele. Journal of Molecular Biology, 404(1), 90-99.