Coenzyme Q10
Coenzyme Q10: Ubiquinone bakeng sa Bophelo bo Botle le Matla
Coenzyme Q10 (CoQ10), e tsejoang hape e le ubiquinone, ke motsoako o qhibilihang mafura o bapalang karolo ea bohlokoa tlhahisong ea matla a sele le tšireletso ea antioxidant. Kaha e teng ka tlhaho mitochondria ea lisele, CoQ10 ea bohlokoa bakeng sa tlhahiso ea ATP (adenosine triphosphate), chelete ea mantlha ea matla a lisele. Sebopeho sa eona se nang le oxidized, ubiquinone, se bohlokoa haholo bakeng sa ho boloka bophelo bo botle ba sele le matla.
Tsoelo-pele ho Biology ea Maiketsetso
Tsoelo-pele ho Biology ea Maiketsetso: Tlhahiso ea Ubiquinone e Thehiloeng ho Beliso
Tlhahiso e Thehiloeng ho Beliso: Tsoelo-pele baelojing ea maiketsetso e nolofalitse tlhahiso e sebetsang ea ubiquinone ka mekhoa ea ho belisa ho sebelisoa likokoana-hloko tse fetotsoeng liphatsa tsa lefutso. Mokhoa ona o tšoarella haholoanyane ebile o theko e tlaase ha o bapisoa le tlhahiso ea lik'hemik'hale tsa setso.
1. Botsitso:
Tlhahiso e thehiloeng ho belisoa e sebelisa mehloli e nchafatsoang 'me e fokotsa tšusumetso ea tikoloho. E fokotsa tlhoko ea lik'hemik'hale tse matla le lits'ebetso tse sebelisang matla a mangata tse amanang le tlhahiso ea lik'hemik'hale.
2. Bokgoni le ho Kgolofala:
Likokoana-hloko tse entsoeng ka liphatsa tsa lefutso, tse kang libaktheria le tomoso, li ka ntlafatsoa ho hlahisa chai e phahameng ea ubiquinone. Sena se lumella tlhahiso e kholo ho fihlela tlhoko e ntseng e hola ea tlatsetso ena ea bohlokoa.
3. Ho Tsitsa le ho Hloeka:
Mekhoa ea ho belisa e netefatsa boleng bo tsitsitseng le bohloeki ba ubiquinone, e leng ea bohlokoa bakeng sa ho boloka maemo le katleho ea sehlahisoa.
Litlhaloso: 98%/ USP/ EP
E qhibilihang ka metsing: 10%/ 20%/ 40%
Bokgoni: 150MT/A
Tlhahiso ea Matla
Mokhoa: Ubiquinone ke karolo ea bohlokoa ea ketane ea lipalangoang tsa lielektrone tsa mitochondrial, e leng ea bohlokoa bakeng sa tlhahiso ea ATP. Ka ho nolofatsa phetiso ea lielektrone, CoQ10 e thusa ho hlahisa matla a hlokahalang bakeng sa lits'ebetso tse fapaneng tsa sele.
Bopaki bo Tshehetsang: Phuputso ho BioFactors (2008) e bontshitse hore tlatsetso ya CoQ10 e ntlafaditse tshebetso ya mitochondrial le tlhahiso ya ATP, e leng se lebisang maemong a matla a ntlafetseng le ho fokotsa mokhathala ho batho ba nang le mathata a mitochondrial (Littarru & Tiano, 2007).
Tšireletso ea Antioxidant
Mokhoa: Jwalo ka antioxidant, ubiquinone e sireletsa disele tshenyong ya oxidative ka ho fokotsa di-free radicals. Sena se thusa ho thibela ho kenngwa ha lipid peroxidation le tshenyo ho diprotheine le DNA, tse bohlokwa bakeng sa bophelo bo botle ba disele le ho phela nako e telele.
Bopaki bo Tshehetsang: Diphuputso tse phatlaladitsweng ho Mitochondrion (2007) di totobaditse karolo ya CoQ10 ho fokotseng kgatello ya oxidative le ho sireletsa kgahlanong le tshenyo ya sele dithutong tsa in vitro le in vivo (Crane, 2001). Phuputso e nngwe ho Free Radical Biology and Medicine (2009) e fumane hore tlatsetso ya CoQ10 e fokotsa matshwao a tshenyo ya oxidative ho batho ba tsofetseng (Bentinger et al., 2007).
Bophelo bo Botle ba Pelo le Methapo ea Metsi
Mokhoa: CoQ10 e tšehetsa bophelo bo botle ba pelo le methapo ea mali ka ho ntlafatsa ts'ebetso ea endothelial, ho fokotsa khatello ea oxidative, le ho ntlafatsa ts'ebetso ea mitochondrial liseleng tsa pelo. E boetse e thusa ho boloka khatello ea mali le maemo a cholesterol a phetseng hantle.
Bopaki bo Tshehetsang: Phuputso e ho Journal of Human Hypertension (2007) e bontshitse hore tlatsetso ya CoQ10 e fokotsa kgatello ya madi haholo ho bakudi ba nang le kgatello e phahameng ya madi (Rosenfeldt et al., 2007). Phuputso e nngwe ho Atherosclerosis (2008) e fumane hore CoQ10 e ntlafaditse tshebetso ya endothelial mme e fokotsa kgatello ya oxidative ho bakudi ba nang le lefu la methapo ya pelo (Langsjoen et al., 2008).
Qetello
Ubiquinone (CoQ10) ke motsoako oa bohlokoa bakeng sa tlhahiso ea matla, tšireletso ea antioxidant, le bophelo bo botle ba pelo le methapo ea mali. Karolo ea eona ho tšehetseng ts'ebetso ea mitochondrial le ho sireletsa khahlanong le khatello ea oxidative e etsa hore e be tlatsetso ea bohlokoa bakeng sa ho khothaletsa bophelo bo botle le matla ka kakaretso. Tsoelo-pele ea baeloji ea maiketsetso e ntlafalitse tlhahiso ea ubiquinone haholo, e etsa hore e be e tsitsitseng le e fumanehang habonolo. Ha lipatlisiso li ntse li tsoela pele, ubiquinone e na le bokhoni bo boholo ba ho tšehetsa botsofali bo phetseng hantle le ho ntlafatsa boleng ba bophelo.
Litšupiso
1. Littarru, GP, & Tiano, L. (2007). Likarolo tsa bongaka tsa coenzyme Q10: ntjhafatso. BioFactors, 32(1-4), 73-80.
2. Crane, FL (2001). Mesebetsi ea lik'hemik'hale tsa biochemical ea coenzyme Q10. Journal of the American College of Nutrition, 20(6), 591-598.
3. Bentinger, M., Brismar, K., & Dallner, G. (2007). Karolo ea coenzyme Q. Mitochondrion ea antioxidant.
4. Rosenfeldt, F., Hilton, D., Pepe, S., & Krum, H. (2007). Tlhahlobo e hlophisitsoeng ea phello ea coenzyme Q10 boikoetlisong ba 'mele, khatello e phahameng ea mali le ho hloleha ha pelo. Journal of Human Hypertension, 21(4), 297-306.
5. Langsjoen, PH, Langsjoen, AM, & Langsjoen, PH (2008). Tšebeliso ea bongaka ea li-inhibitor tsa HMG CoA-reductase le ho fokotseha ho amanang le coenzyme Q10. Atherosclerosis, 199(2), 174-179.