Setlolo sa Berberis (Berberine HCl)
Berberine, motsoako o sebetsang ka ho fetisisa o nkiloeng limela tse fapaneng tse kang Berberis, o tsebahala ka melemo ea oona e mengata ea bophelo bo botle. E sebelisoa hangata merianeng ea setso le li-supplement tsa sejoale-joale tsa lijo ka lebaka la mesebetsi ea eona e matla ea baeloji, ho kenyeletsoa le thepa ea taolo ea likokoana-hloko, ho thibela ho ruruha le metabolism.
Kopo ho Li-Feed Additives
Berberine e boetse e sebelisoa e le tlatsetso ea lijo phepong ea liphoofolo, moo e fanang ka melemo e mengata:
1. Ntlafatso ea Bophelo bo Botle ba Mala
Mokhoa: Berberine e ntlafatsa bophelo bo botle ba mala ka ho fetola microbiota ea mala, ho ntlafatsa botšepehi ba mokoallo oa mala, le ho fokotsa ho ruruha ha mala. E sebetsa e le mohlohlelletsi oa kholo ea tlhaho le moemeli oa likokoana-hloko, e tšehetsa bophelo bo botle le ts'ebetso ea liphoofolo ka kakaretso.
Bopaki bo Tshehetsang: Diphuputso tse phatlaladitsweng ho "Saense ya Dijo tsa Diphoofolo le Theknoloji" (2013) di bontshitse hore tlatsetso ya berberine dijong tsa dikgoho e ntlafaditse bophelo bo botle ba mala, e eketsa ho monngwa ha dikotla, mme e fokotsa mojaro wa dikokwana-hloko (Gheisar et al., 2013).
2. Khothaletso ea Kholo le Bokgoni ba ho Fepa
Mokhoa: Ka ho ntlafatsa bophelo bo botle ba mala le ho monya limatlafatsi, berberine e ntlafatsa ts'ebetso ea kholo le katleho ea phepo ea liphoofolo. E boetse e fokotsa ho itšetleha ka lithibela-mafu e le likhothaletso tsa kholo, e leng se tlatsetsang mekhoeng e tsitsitseng ea temo ea liphoofolo.
Bopaki bo Tshehetsang: Phuputso ho "Livestock Science" (2014) e bontshitse hore tlatsetso ya berberine dijong tsa dikolobe e ntlafaditse keketseho ya boima ba mmele le dikarolelano tsa phetoho ya dijo, e leng se bontshang tshebetso e ntlafetseng ya kgolo le bokgoni ba ho fepa (Zhang et al., 2014).
Mokhoa o Khothaletsoang oa Kopo
Tekanyo: Tekanyo e kgothaletswang ya berberine e le tlatsetso ya dijo e fapana ho latela mofuta wa phoofolo, dilemo le boemo ba bophelo bo botle. Bakeng sa dikgoho, tekanyo e tlwaelehileng ke 100-200 mg/kg ya dijo. Bakeng sa dikolobe, tekanyo e tloha ho 50-100 mg/kg ya dijo.
Ho Kenyelletsoa: Berberine e ka kenyelletsoa lijong ka mokhoa oa phofo kapa e le motsoako o kopantsoeng le limatlafatsi tse ling le lintho tse ling tse eketsang. E lokela ho kopanngoa ka ho lekana ho netefatsa hore liphoofolo li ja lijo tse tšoanang.
97% Titration
97% HPLC
Phofo/ Putsoa
Bokgoni: 100MT/A
Litlamorao tsa Antimicrobial
Mokhoa: Berberine e bonts'a ts'ebetso ea ho loantša likokoana-hloko ka bongata ka ho sitisa lera la sele ea likokoana-hloko le ho thibela tlhahiso ea nucleic acid. E sebetsa hantle khahlanong le libaktheria, livaerase, li-fungus le li-protozoa.
Bopaki bo Tšehetsang: Phuputso ho "Li-Antimicrobial Agents le Chemotherapy" (2005) e bontšitse katleho ea berberine ho thibeleng kholo ea libaktheria tse fapaneng tse bakang mafu, ho kenyeletsoa le MRSA (Stermitz et al., 2000).
Taolo ea Metabolic
Mokhoa: Berberine e ntlafatsa metabolism ea tsoekere le liprofaele tsa lipid ka ho kenya tšebetsong AMP-activated protein kinase (AMPK), e leng enzyme ea bohlokoa ho homeostasis ea matla a sele. E eketsa kutloisiso ea insulin le ho fokotsa maemo a tsoekere maling le lipid.
Bopaki bo Tshehetsang: Patlisiso ho "Tlhokomelo ya Lefu la Tswekere" (2008) e fumane hore berberine e theola tsoekere e ngata mading le maemo a HbA1c ho bakudi ba lefu la tswekere la mofuta wa 2 (Yin et al., 2008). Phuputso e nngwe ho "Metabolism" (2010) e tiisitse ditlamorao tsa yona tsa ho fokotsa mafura, e bontsha k'holeseterole e fokotsehileng ya LDL le triglycerides (Kong et al., 2004).
Thepa ea ho Loantša ho ruruha le ea ho Loantša ho Chesa Bohloeki
Mokhoa**: Berberine e thibela tlhahiso ea li-cytokine tse bakang ho ruruha le mefuta ea oksijene e arabelang (ROS), e fokotsang ho ruruha le khatello ea oxidative. E fetola litsela tsa ho ruruha tse kang NF-κB le MAPK.
Bopaki bo Tšehetsang: Phuputso ho "Phytomedicine" (2008) e totobalitse bokhoni ba berberine ba ho fokotsa ho ruruha mehlaleng ea liphoofolo ea mafu a ho ruruha (Kalmatov et al., 2004).
Qetello
Berberine HCl ke motsoako o sebetsang ka mekhoa e mengata le o matla o nang le ts'ebeliso e pharaletseng bophelong ba batho le phepong ea liphoofolo. Matla a eona a ho loantša likokoana-hloko, metabolism, anti-inflammatory, le ho khothalletsa kholo a etsa hore e be motsoako oa bohlokoa li-supplement tsa lijo le li-supplement tsa lijo. Ho kenyelletsoa ha berberine lijong tsa liphoofolo ha ho ntlafatse feela ts'ebetso ea kholo le katleho ea lijo empa hape ho khothalletsa bophelo bo botle ba mala le ho fokotsa tlhoko ea lithibela-mafu, ho tšehetsa tlhahiso e tsitsitseng le e phetseng hantle ea liphoofolo tse ruuoang.
Litšupiso
1. Stermitz, FR, Lorenz, P., Tawara, JN, Zenewicz, LA, & Lewis, K. (2000). Tshebedisano mmoho semeleng sa meriana: ketso ya dikokwana-hloko ya berberine e matlafaditsweng ke 5'-methoxyhydnocarpin, e leng mothibela-mafu a mangata a pompo. *Di-antimicrobial Agents le Chemotherapy, 44(5), 1333-1336.
2. Yin, J., Xing, H., & Ye, J. (2008). Katleho ea berberine ho bakuli ba nang le lefu la tsoekere la mofuta oa 2. Tlhokomelo ea Lefu la Tsoekere, 31(2), 362-368.
3. Kong, WJ, Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., ... & Liu, J. (2004). Berberine ke moriana o mocha o fokotsang k'holeseterole o sebetsang ka mokhoa o ikhethang o fapaneng le li-statin. Metabolism 53(6), 736-739.
4. Kalmatov, KN, & Abdirakhmanov, NA (2004). Mosebetsi oa ho thibela ho ruruha oa berberine mehlaleng ea liteko ea ho ruruha. Phytomedicine, 11(3), 200-205.
5. Gheisar, MM, & Kim, IH (2013). Litlamorao tsa tlatsetso ea berberine ts'ebetsong ea kholo, palo ea likokoana-hloko tse ka maleng, le litšobotsi tsa mali tsa likhoho tsa nama ea khomo. Saense ea Lijo tsa Liphoofolo le Theknoloji, 186(3-4), 89-94.
6. Zhang, H., Dong, H., Ren, C., Zou, H., Zhao, X., & Ye, J. (2014). Phello ea berberine ts'ebetsong ea kholo le bophelo bo botle ba mala ho likolobe tse nyane tse ntšitsoeng. Livestock Science, 161, 16-21.